Training related changes in cognitive abilities and neural plasticity

Institution: Cardiff University Investigator(s): Dr. Claudia Metzler-Baddeley, Dr, Derek Jones, Professor Karen Caeyenberghs Program: Cogmed RM, 8 weeks Background & Aim: The purpose of the present study is to investigate plasticity changes in white matter microstructure related to task-specific as well as near and far transfer effects of eight weeks of Cogmed Working Memory Training. The effects of 2 months of Cogmed training on general cognitive abilities will be measured with a number of reasoning and working memory tasks, as well as the impact on gray and white matter microstructure in the brain, using novel diffusion MRI based methods to measure axon density Population & Sample Size: N = 40 healthy adults, ages 20 – 40 years without a history of neurological or psychiatric disease, head injury, and alcohol/drug abuse Design: Randomized, Placebo Controlled, Test-retest, MRI