Cogmed for children with brain tumor receiving cranial radiation therapy

Institution: Children’s National Medical Center

Investigator(s):! Dr. Kristina Hardy

Program: Cogmed RM

Background & Aim: Pediatric brain tumors are often treated with some combination of neurosurgery, chemotherapy and cranial radiation therapy (CRT). Advances in treatment have increased the likelihood of cure but, survival for these children is often characterized by significant deficits in attention and working memory (WM). Survivors thus have difficulties processing and storing new information which contributes to declines in IQ and academic functioning over time. Later, these effects lead to limited vocational opportunities and reduced likelihood of independent living. Thus, there is a critical need for interventions to mitigate deficits and/or restore cognitive functioning in this population. The aim of this study is to establish the feasibility and preliminary efficacy of WM training for children who have received CRT after brain tumor.

Population & Sample Size: N = 60 children with brain tumor, ages 5 -16 years (2-4 months post radiation)

Design: Randomized, Placebo controlled, Single-blinded, Test-retest, 6 month follow-up