Changes in cortical dopamine D1 receptor binding associated with cognitive training

Institution: Karolinska Institute

Title: Changes in cortical dopamine D1 receptor binding associated with cognitive training

Researcher(s): Fiona McNab, Andrea Varrone, Lars Farde, Aurelija Jucaite, Paulina Bystritsky, Hans Forssberg, Torkel Klingberg

Research: Cogmed RM

Published: Science, February 2009

Funding: This work was supported by the Swedish Foundation for Strategic Research, Swedish Research Council, VINNOVA (the Swedish Governmental Agency for Innovation Systems), and Knut and Alice Wallenberg Foundation. Training program, investigator training, and technical support provided by Cogmed. No funding provided by Cogmed.

Abstract
Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

Science, 323, 800 (2009)

Link to abstract